Ontology highlight
ABSTRACT:
SUBMITTER: Sapoznik S
PROVIDER: S-EPMC5005261 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Sapoznik Stav S Bahar-Shany Keren K Brand Hadar H Pinto Yishay Y Gabay Orshay O Glick-Saar Efrat E Dor Chen C Zadok Oranit O Barshack Iris I Zundelevich Adi A Gal-Yam Einav Nili EN Yung Yuval Y Hourvitz Ariel A Korach Jacob J Beiner Mario M Jacob Jasmine J Levanon Erez Y EY Barak Michal M Aviel-Ronen Sarit S Levanon Keren K
Neoplasia (New York, N.Y.) 20160201 2
In recent years, the notion that ovarian carcinoma results from ovulation-induced inflammation of the fallopian tube epithelial cells (FTECs) has gained evidence. However, the mechanistic pathway for this process has not been revealed yet. In the current study, we propose the mutator protein activation-induced cytidine deaminase (AID) as a link between ovulation-induced inflammation in FTECs and genotoxic damage leading to ovarian carcinogenesis. We show that AID, previously shown to be function ...[more]