Islet beta cell failure in type 2 diabetes.
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ABSTRACT:
SUBMITTER: Prentki M
PROVIDER: S-EPMC1483155 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Publications
Islet beta cell failure in type 2 diabetes.
Prentki Marc M Nolan Christopher J CJ
The Journal of clinical investigation 20060701 7
The major focus of this Review is on the mechanisms of islet beta cell failure in the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of beta cell compensation for insulin resistance, consideration is also given to the mechanisms involved in the compensation process, including mechanisms for expansion of beta cell mass and for enhanced beta cell performance. The importance of genetic, intrauterine, and environmental factors in the determination ...[more]
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