Ontology highlight
ABSTRACT:
SUBMITTER: Avall K
PROVIDER: S-EPMC4443338 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20150504 20
Insulin resistance and β-cell failure are the major defects in type 2 diabetes mellitus. However, the molecular mechanisms linking these two defects remain unknown. Elevated levels of apolipoprotein CIII (apoCIII) are associated not only with insulin resistance but also with cardiovascular disorders and inflammation. We now demonstrate that local apoCIII production is connected to pancreatic islet insulin resistance and β-cell failure. An increase in islet apoCIII causes promotion of a local inf ...[more]