Mitochondrial defects in cancer.
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ABSTRACT:
SUBMITTER: Carew JS
PROVIDER: S-EPMC149412 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Publications
Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progression of cancer. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in various types of cancer, and offer some perspective as to the emergence of mtDNA mutations, their functional ...[more]
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