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Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.

ABSTRACT: The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficits are analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP, a component of the WAVE-1 signaling network. Thus WAVE-1 is required for normal neural functioning.

SUBMITTER: Soderling SH

PROVIDER: S-EPMC149900 | biostudies-literature | 2003 Feb

REPOSITORIES: biostudies-literature

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Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.

Soderling Scott H SH Langeberg Lorene K LK Soderling Jacquelyn A JA Davee Stephen M SM Simerly Richard R Raber Jacob J Scott John D JD

Proceedings of the National Academy of Sciences of the United States of America 20030210 4

The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficit ...[more]

PMID: 12578964

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