Ontology highlight
ABSTRACT:
SUBMITTER: Hong Q
PROVIDER: S-EPMC6468042 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Hong Qiang Q Li Cong C Ying Ruhong R Lin Heming H Li Jingqiu J Zhao Yu Y Cheng Hanhua H Zhou Rongjia R
Protein & cell 20181226 5
Folliculogenesis is essential for production of female gametes in vertebrates. However, the molecular mechanisms underlying follicle development, particularly apoptosis regulation in ovary, remain elusive. Here, we generated sox3 knockout zebrafish lines using CRISPR/Cas9. sox3 knockout led to follicle development retardation and a reduced fecundity in females. Comparative analysis of transcriptome between sox3<sup>-/-</sup> and wild-type ovaries revealed that Sox3 was involved in pathways of ov ...[more]