Ontology highlight
ABSTRACT:
SUBMITTER: Collin M
PROVIDER: S-EPMC150189 | biostudies-literature | 2001 Jun
REPOSITORIES: biostudies-literature
The EMBO journal 20010601 12
Streptococcus pyogenes is an important human pathogen that selectively interacts with proteins involved in the humoral defense system, such as immunoglobulins and complement factors. In this report we show that S.pyogenes has the ability to hydrolyze the chitobiose core of the asparagine-linked glycan on immuno globulin G (IgG) when bacteria are grown in the presence of human plasma. This activity is associated with the secretion of a novel 108 kDa protein denoted EndoS. EndoS has endoglycosidas ...[more]