Ontology highlight
ABSTRACT:
SUBMITTER: Frick IM
PROVIDER: S-EPMC3020741 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Frick Inga-Maria IM Shannon Oonagh O Åkesson Per P Mörgelin Matthias M Collin Mattias M Schmidtchen Artur A Björck Lars L
The Journal of biological chemistry 20101110 2
Recent studies have shown that activation of complement and contact systems results in the generation of antibacterial peptides. Streptococcus pyogenes, a major bacterial pathogen in humans, exists in >100 different serotypes due to sequence variation in the surface-associated M protein. Cases of invasive and life-threatening S. pyogenes infections are commonly associated with isolates of the M1 serotype, and in contrast to the large majority of M serotypes, M1 isolates all secrete the SIC prote ...[more]