Ontology highlight
ABSTRACT:
SUBMITTER: Nishida M
PROVIDER: S-EPMC150196 | biostudies-literature | 2001 Jun
REPOSITORIES: biostudies-literature
Nishida M M Nagata K K Hachimori Y Y Horiuchi M M Ogura K K Mandiyan V V Schlessinger J J Inagaki F F
The EMBO journal 20010601 12
Vav is a guanine nucleotide exchange factor for the Rho/Rac family that is expressed exclusively in hematopoietic cells. Growth factor receptor-bound protein 2 (Grb2) has been proposed to play important roles in the membrane localization and activation of Vav through dimerization of its C-terminal Src-homology 3 (SH3) domain (GrbS) and the N-terminal SH3 domain of Vav (VavS). The crystal structure of VavS complexed with GrbS has been solved. VavS is distinct from other SH3 domain proteins in tha ...[more]