CREB regulates AChE-R-induced proliferation of human glioblastoma cells.
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ABSTRACT:
SUBMITTER: Perry C
PROVIDER: S-EPMC1502102 | biostudies-literature | 2004 May-Jun
REPOSITORIES: biostudies-literature
Publications
CREB regulates AChE-R-induced proliferation of human glioblastoma cells.
Perry Chava C Sklan Ella H EH Soreq Hermona H
Neoplasia (New York, N.Y.) 20040501 3
The cyclic adenosine monophosphate (AMP) response element-binding protein, CREB, often modulates stress responses. Here, we report that CREB suppresses the glioblastoma proliferative effect of the stress-induced acetylcholinesterase variant, AChE-R. In human U87MG glioblastoma cells, AChE-R formed a triple complex with protein kinase C (PKC) epsilon and the scaffold protein RACK1, enhanced PKCepsilon phosphorylation, and facilitated BrdU incorporation. Either overexpressed CREB, or antisense des ...[more]
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