Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC4096426 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Sun Yuyang Y Sukumaran Pramod P Varma Archana A Derry Susan S Sahmoun Abe E AE Singh Brij B BB
Biochimica et biophysica acta 20140425 9
Cholesterol has been shown to promote cell proliferation/migration in many cells; however the mechanism(s) have not yet been fully identified. Here we demonstrate that cholesterol increases Ca(2+) entry via the TRPM7 channel, which promoted proliferation of prostate cells by inducing the activation of the AKT and/or the ERK pathway. Additionally, cholesterol mediated Ca(2+) entry induced calpain activity that showed a decrease in E-cadherin expression, which together could lead to migration of p ...[more]