Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus.
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ABSTRACT:
SUBMITTER: Baechler EC
PROVIDER: S-EPMC151388 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
Publications
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus.
Baechler Emily C EC Batliwalla Franak M FM Karypis George G Gaffney Patrick M PM Ortmann Ward A WA Espe Karl J KJ Shark Katherine B KB Grande William J WJ Hughes Karis M KM Kapur Vivek V Gregersen Peter K PK Behrens Timothy W TW
Proceedings of the National Academy of Sciences of the United States of America 20030225 5
Systemic lupus erythematosus (SLE) is a complex, inflammatory autoimmune disease that affects multiple organ systems. We used global gene expression profiling of peripheral blood mononuclear cells to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls. Strikingly, about half of the patients studied showed dysregulated expression of genes in the IFN pathway. Furthermore, this IFN gene expression "signature" served as a marker for more severe dise ...[more]
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