Ontology highlight
ABSTRACT:
SUBMITTER: Visalli MA
PROVIDER: S-EPMC151746 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Visalli Melissa A MA Murphy Ellen E Projan Steven J SJ Bradford Patricia A PA
Antimicrobial agents and chemotherapy 20030201 2
Tigecycline has good broad-spectrum activity against many gram-positive and gram-negative pathogens with the notable exception of the PROTEEAE: A study was performed to identify the mechanism responsible for the reduced susceptibility to tigecycline in Proteus mirabilis. Two independent transposon insertion mutants of P. mirabilis that had 16-fold-increased susceptibility to tigecycline were mapped to the acrB gene homolog of the Escherichia coli AcrRAB efflux system. Wild-type levels of decreas ...[more]