Ontology highlight
ABSTRACT:
SUBMITTER: Kitagawa D
PROVIDER: S-EPMC1523180 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Kitagawa Daiju D Kajiho Hiroaki H Negishi Takahiro T Ura Seiji S Watanabe Tomomi T Wada Teiji T Ichijo Hidenori H Katada Toshiaki T Nishina Hiroshi H
The EMBO journal 20060629 14
Stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) responds to a variety of stress stimuli and controls cell fates such as cell cycle entrance, apoptosis and senescence. Stimuli such as ultraviolet irradiation and chemical reagents that damage genomic DNA induce the activation of the SAPK/JNK signaling pathway. However, it is unclear how the signal arising in the nucleus owing to DNA damage is transmitted to SAPK/JNK in the cytoplasm. Here, we report that the nuclear components D ...[more]