Ontology highlight
ABSTRACT:
SUBMITTER: Kiefer F
PROVIDER: S-EPMC452527 | biostudies-other | 1996 Dec
REPOSITORIES: biostudies-other
Kiefer F F Tibbles L A LA Anafi M M Janssen A A Zanke B W BW Lassam N N Pawson T T Woodgett J R JR Iscove N N NN
The EMBO journal 19961201 24
In mammalian cells, a specific stress-activated protein kinase (SAPK/JNK) pathway is activated in response to inflammatory cytokines, injury from heat, chemotherapeutic drugs and UV or ionizing radiation. The mechanisms that link these stimuli to activation of the SAPK/JNK pathway in different tissues remain to be identified. We have developed and applied a PCR-based subtraction strategy to identify novel genes that are differentially expressed at specific developmental points in hematopoiesis. ...[more]