Haplotype block structure is conserved across mammals.
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ABSTRACT:
SUBMITTER: Guryev V
PROVIDER: S-EPMC1523234 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Publications
Haplotype block structure is conserved across mammals.
Guryev Victor V Smits Bart M G BM van de Belt Jose J Verheul Mark M Hubner Norbert N Cuppen Edwin E
PLoS genetics 20060701 7
Genetic variation in genomes is organized in haplotype blocks, and species-specific block structure is defined by differential contribution of population history effects in combination with mutation and recombination events. Haplotype maps characterize the common patterns of linkage disequilibrium in populations and have important applications in the design and interpretation of genetic experiments. Although evolutionary processes are known to drive the selection of individual polymorphisms, the ...[more]
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