Ontology highlight
ABSTRACT:
SUBMITTER: Levran O
PROVIDER: S-EPMC3075619 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Levran Orna O Awolesi Olaoluwakitan O Linzy Shirley S Adelson Miriam M Kreek Mary Jeanne MJ
Journal of human genetics 20101216 2
The opioid system is involved in the action of opiate drugs, opioid addiction, pain experience and analgesia. Individual differences in opioid effect may be attributed in part to genetic variations. Long-range cis regulatory elements and intronic variants are potential sources of functional diversity. Recently, we have detected association of two intronic OPRM1 variants with heroin addiction in European Americans. In this study, we analyzed the genetic variations in the OPRM1 100 kb 5'-flanking ...[more]