Ontology highlight
ABSTRACT:
SUBMITTER: Singh B
PROVIDER: S-EPMC152354 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Singh Bhuvanesh B Reddy Pabbathi G PG Goberdhan Andy A Walsh Christine C Dao Su S Ngai Ivan I Chou Ting Chao TC O-Charoenrat Pornchai P Levine Arnold J AJ Rao Pulivarthi H PH Stoffel Archontoula A
Genes & development 20020401 8
Interactions between the p53 and PI3K/AKT pathways play a significant role in the determination of cell death/survival. In benign cells these pathways are interrelated through the transcriptional regulation of PTEN by p53, which is required for p53-mediated apoptosis. PTEN exerts its effects by decreasing the phosphorylated AKT fraction, thereby diminishing prosurvival activities. However, the link between these pathways in cancer is not known. In this study, PIK3CA, encoding the p110alpha catal ...[more]