Ontology highlight
ABSTRACT:
SUBMITTER: Kostareli E
PROVIDER: S-EPMC3668826 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Kostareli Efterpi E Holzinger Dana D Bogatyrova Olga O Hielscher Thomas T Wichmann Gunnar G Keck Michaela M Lahrmann Bernd B Grabe Niels N Flechtenmacher Christa C Schmidt Christopher R CR Seiwert Tanguy T Dyckhoff Gerhard G Dietz Andreas A Höfler Daniela D Pawlita Michael M Benner Axel A Bosch Franz X FX Plinkert Peter P Plass Christoph C Weichenhan Dieter D Hess Jochen J
The Journal of clinical investigation 20130501 6
High-risk types of human papilloma virus (HPV) are increasingly associated with oropharyngeal squamous cell carcinoma (OPSCC). Strikingly, patients with HPV-positive OPSCC are highly curable with ionizing radiation and have better survival compared with HPV-negative patients, but the underlying molecular mechanisms remain poorly understood. We applied an array-based approach to monitor global changes in CpG island hypermethylation between HPV-negative and HPV-positive OPSCCs and identified a spe ...[more]