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Imipenem resistance in a Salmonella clinical strain due to plasmid-mediated class A carbapenemase KPC-2.


ABSTRACT: A Salmonella enterica serotype Cubana isolate exhibiting resistance to most beta-lactam antibiotics, including oxyimino-cephalosporins and imipenem, was isolated from a 4-year-old boy with gastroenteritis in Maryland. beta-Lactam resistance was mediated by a conjugative plasmid that encoded KPC-2, a class A carbapenemase previously found in a Klebsiella pneumoniae isolate from the Maryland area as well. Sequence analysis of the flanking regions indicated a potential association of bla(KPC-2) with mobile structures.

SUBMITTER: Miriagou V 

PROVIDER: S-EPMC152505 | biostudies-literature | 2003 Apr

REPOSITORIES: biostudies-literature

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Imipenem resistance in a Salmonella clinical strain due to plasmid-mediated class A carbapenemase KPC-2.

Miriagou Vivi V   Tzouvelekis Leonidas S LS   Rossiter Shannon S   Tzelepi Eva E   Angulo Frederick J FJ   Whichard Jean M JM  

Antimicrobial agents and chemotherapy 20030401 4


A Salmonella enterica serotype Cubana isolate exhibiting resistance to most beta-lactam antibiotics, including oxyimino-cephalosporins and imipenem, was isolated from a 4-year-old boy with gastroenteritis in Maryland. beta-Lactam resistance was mediated by a conjugative plasmid that encoded KPC-2, a class A carbapenemase previously found in a Klebsiella pneumoniae isolate from the Maryland area as well. Sequence analysis of the flanking regions indicated a potential association of bla(KPC-2) wit  ...[more]

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