Ontology highlight
ABSTRACT:
SUBMITTER: Poirel L
PROVIDER: S-EPMC7526841 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Poirel Laurent L Vuillemin Xavier X Juhas Mario M Masseron Amandine A Bechtel-Grosch Ursina U Tiziani Simon S Mancini Stefano S Nordmann Patrice P
Antimicrobial agents and chemotherapy 20200722 8
KPC-50 is a KPC-3 variant identified from a <i>Klebsiella pneumoniae</i> clinical isolate recovered in Switzerland in 2019. Compared to KPC-3, KPC-50 shows (i) a three-amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277, (ii) an increased affinity to ceftazidime, (iii) a decreased sensitivity to avibactam, explaining the ceftazidime-avibactam resistance, and (iv) an association with a sharp reduction of its carbapenemase activity. ...[more]