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Telomeric silencing of an open reading frame in Saccharomyces cerevisiae.


ABSTRACT: The endmost chromosome I ORF is silenced by a natural telomere position effect. YAR073W/IMD1 was found to be transcribed at much higher levels in sir3 mutants and when its adjacent telomere was removed from it. These results suggest that telomeres play a role in silencing actual genes.

SUBMITTER: Barton AB 

PROVIDER: S-EPMC1526490 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

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Telomeric silencing of an open reading frame in Saccharomyces cerevisiae.

Barton Arnold B AB   Kaback David B DB  

Genetics 20060402 2


The endmost chromosome I ORF is silenced by a natural telomere position effect. YAR073W/IMD1 was found to be transcribed at much higher levels in sir3 mutants and when its adjacent telomere was removed from it. These results suggest that telomeres play a role in silencing actual genes. ...[more]

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