Ontology highlight
ABSTRACT:
SUBMITTER: Smith JE
PROVIDER: S-EPMC4105149 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Cell reports 20140612 6
High-throughput gene expression analysis has revealed a plethora of previously undetected transcripts in eukaryotic cells. In this study, we investigate >1,100 unannotated transcripts in yeast predicted to lack protein-coding capacity. We show that a majority of these RNAs are enriched on polyribosomes akin to mRNAs. Ribosome profiling demonstrates that many bind translocating ribosomes within predicted open reading frames 10-96 codons in size. We validate expression of peptides encoded within a ...[more]