Ontology highlight
ABSTRACT:
SUBMITTER: Chabes AL
PROVIDER: S-EPMC153024 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Chabes Anna Lena AL Pfleger Cathie M CM Kirschner Marc W MW Thelander Lars L
Proceedings of the National Academy of Sciences of the United States of America 20030324 7
Ribonucleotide reductase consists of two nonidentical proteins, R1 and R2, and catalyzes the rate-limiting step in DNA precursor synthesis: the reduction of ribonucleotides to deoxyribonucleotides. A strictly balanced supply of deoxyribonucleotides is essential for both accurate DNA replication and repair. Therefore, ribonucleotide reductase activity is under exquisite control both transcriptionally and posttranscriptionally. In proliferating mammalian cells, enzyme activity is regulated by cont ...[more]