Ontology highlight
ABSTRACT:
SUBMITTER: Rahimi H
PROVIDER: S-EPMC4578213 | biostudies-literature | 2015 Jan-Feb
REPOSITORIES: biostudies-literature
Rahimi H H Negahdari B B Shokrgozar M A MA Madadkar-Sobhani A A Mahdian R R Foroumadi A A Amin M Kafshdouzi MK Karimipoor M M
Research in pharmaceutical sciences 20150101 1
Anaphase promoting complex (APC) controls cell cycle and chromosome segregation. The APC activation occurs after binding of co-activators, cdh1 and cdc20. Cdh1 plays a role in cancer pathogenesis and is known as a potential drug target. The main aim of this study was prediction of 3D structure of cdh1 and designing the inhibitory compounds based on the structural model. First, 3D structure of cdh1 was predicted by means of homology modelling and molecular dynamics tools, MODELLER and Gromacs pac ...[more]