Ontology highlight
ABSTRACT:
SUBMITTER: da Fonseca PC
PROVIDER: S-EPMC153026 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
da Fonseca Paula C A PC Morris Stephen A SA Nerou Edmund P EP Taylor Colin W CW Morris Edward P EP
Proceedings of the National Academy of Sciences of the United States of America 20030321 7
The inositol 1,4,5-trisphosphate receptor (IP(3)R) is a tetrameric intracellular Ca(2+) channel, which mediates the release of Ca(2+) from the endoplasmic reticulum in response to many different extracellular stimuli. We present a 3D structure of the type 1 IP(3)R obtained by electron microscopy and single-particle analysis that reveals its domain organization. The IP(3)R has a flower-like appearance with fourfold symmetry and is made up of three distinct domains connected by slender links. By r ...[more]