Ontology highlight
ABSTRACT:
SUBMITTER: Morlon A
PROVIDER: S-EPMC153033 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Morlon Aurore A Sassone-Corsi Paolo P
Proceedings of the National Academy of Sciences of the United States of America 20030318 7
Proteins with LIM domains have been implicated in transcriptional regulation. The four and half LIM domain (FHL) group of LIM-only proteins is composed of five members, some of which have been shown to have intrinsic activation function. Here we show that FHL2 is the only member of the family whose expression is inducible upon serum stimulation in cultured cells. Induction of FHL2 is coordinated in time with the increased levels of two early-response products, the oncoproteins Fos and Jun. FHL2 ...[more]