Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.
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ABSTRACT:
SUBMITTER: Lindenbach BD
PROVIDER: S-EPMC1533780 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Publications
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.
Lindenbach Brett D BD Meuleman Philip P Ploss Alexander A Vanwolleghem Thomas T Syder Andrew J AJ McKeating Jane A JA Lanford Robert E RE Feinstone Stephen M SM Major Marian E ME Leroux-Roels Geert G Rice Charles M CM
Proceedings of the National Academy of Sciences of the United States of America 20060216 10
Hepatitis C virus (HCV) is a major cause of chronic liver disease, frequently progressing to cirrhosis and increased risk of hepatocellular carcinoma. Current therapies are inadequate and progress in the field has been hampered by the lack of efficient HCV culture systems. By using a recently described HCV genotype 2a infectious clone that replicates and produces infectious virus in cell culture (HCVcc), we report here that HCVcc strain FL-J6/JFH can establish long-term infections in chimpanzees ...[more]
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