Ontology highlight
ABSTRACT:
SUBMITTER: Steitz TA
PROVIDER: S-EPMC1538561 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
The EMBO journal 20060801 15
The structures of T7 RNA polymerase (T7 RNAP) captured in the initiation and elongation phases of transcription, that of phi29 DNA polymerase bound to a primer protein and those of the multisubunit RNAPs bound to initiating factors provide insights into how these proteins can initiate RNA synthesis and synthesize 6-10 nucleotides while remaining bound to the site of initiation. Structural insight into the translocation of the product transcript and the separation of the downstream duplex DNA is ...[more]