Ontology highlight
ABSTRACT:
SUBMITTER: Lo SC
PROVIDER: S-EPMC1538563 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Lo Shih-Ching SC Li Xuchu X Henzl Michael T MT Beamer Lesa J LJ Hannink Mark M
The EMBO journal 20060803 15
Keap1 is a BTB-Kelch substrate adaptor protein that regulates steady-state levels of Nrf2, a bZIP transcription factor, in response to oxidative stress. We have determined the structure of the Kelch domain of Keap1 bound to a 16-mer peptide from Nrf2 containing a highly conserved DxETGE motif. The Nrf2 peptide contains two short antiparallel beta-strands connected by two overlapping type I beta-turns stabilized by the aspartate and threonine residues. The beta-turn region fits into a binding poc ...[more]