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AG205, a novel agent directed against FabK of Streptococcus pneumoniae.

ABSTRACT: AG205 was identified from high-throughput screening as a potent inhibitor of FabK, the enoyl-ACP reductase in Streptococcus pneumoniae. Specific inhibition of lipid biosynthesis in a macromolecular biosynthesis assay and identification of an Ala141Ser substitution in FabK from spontaneous AG205-resistant mutants indicated that AG205 exerts antibacterial activity against S. pneumoniae through the specific inhibition of FabK.

SUBMITTER: Takahata S

PROVIDER: S-EPMC1538662 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature

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AG205, a novel agent directed against FabK of Streptococcus pneumoniae.

Takahata Sho S Iida Maiko M Osaki Yumi Y Saito Jun J Kitagawa Hideo H Ozawa Tomohiro T Yoshida Takuji T Hoshiko Shigeru S

Antimicrobial agents and chemotherapy 20060801 8

AG205 was identified from high-throughput screening as a potent inhibitor of FabK, the enoyl-ACP reductase in Streptococcus pneumoniae. Specific inhibition of lipid biosynthesis in a macromolecular biosynthesis assay and identification of an Ala141Ser substitution in FabK from spontaneous AG205-resistant mutants indicated that AG205 exerts antibacterial activity against S. pneumoniae through the specific inhibition of FabK. ...[more]

PMID: 16870790

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