Fungal metabolic model for tyrosinemia type 3: molecular characterization of a gene encoding a 4-hydroxy-phenyl pyruvate dioxygenase from Aspergillus nidulans.
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ABSTRACT:
SUBMITTER: da Silva Ferreira ME
PROVIDER: S-EPMC1539140 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
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Fungal metabolic model for tyrosinemia type 3: molecular characterization of a gene encoding a 4-hydroxy-phenyl pyruvate dioxygenase from Aspergillus nidulans.
da Silva Ferreira Márcia Eliana ME Savoldi Marcela M Sueli Bonato Pierina P Goldman Maria Helena S MH Goldman Gustavo H GH
Eukaryotic cell 20060801 8
Mutations in the human HPD gene (encoding 4-hydroxyphenylpyruvic acid dioxygenase) cause hereditary tyrosinemia type 3 (HT3). We deleted the Aspergillus nidulans homologue (hpdA). We showed that the mutant strain is not able to grow in the presence of phenylalanine and that it accumulates increased concentrations of tyrosine and 4-hydroxyphenylpyruvic acid, mimicking the human HT3 phenotype. ...[more]
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