Ontology highlight
ABSTRACT:
SUBMITTER: Durcova-Hills G
PROVIDER: S-EPMC1544062 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Durcova-Hills Gabriela G Hajkova Petra P Sullivan Stephen S Barton Sheila S Surani M Azim MA McLaren Anne A
Proceedings of the National Academy of Sciences of the United States of America 20060717 30
Germ cells in XY male mice establish site-specific methylation on imprinted genes during spermatogenesis, whereas germ cells in XX females establish their imprints in growing oocytes. We showed previously that in vitro, sex-specific methylation patterns of pluripotent stem cell lines derived from germ cells were influenced more by the sex chromosome constitution of the cells themselves than by the gender of the embryo from which they had been derived. To see whether the same situation would prev ...[more]