Ontology highlight
ABSTRACT:
SUBMITTER: Mahadevaraju S
PROVIDER: S-EPMC7873209 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Mahadevaraju Sharvani S Fear Justin M JM Akeju Miriam M Galletta Brian J BJ Pinheiro Mara M L S MMLS Avelino Camila C CC Cabral-de-Mello Diogo C DC Conlon Katie K Dell'Orso Stafania S Dell'Orso Stafania S Demere Zelalem Z Mansuria Kush K Mendonça Carolina A CA Palacios-Gimenez Octavio M OM Ross Eli E Savery Max M Yu Kevin K Smith Harold E HE Sartorelli Vittorio V Yang Haiwang H Rusan Nasser M NM Vibranovski Maria D MD Matunis Erika E Oliver Brian B
Nature communications 20210209 1
Given their copy number differences and unique modes of inheritance, the evolved gene content and expression of sex chromosomes is unusual. In many organisms the X and Y chromosomes are inactivated in spermatocytes, possibly as a defense mechanism against insertions into unpaired chromatin. In addition to current sex chromosomes, Drosophila has a small gene-poor X-chromosome relic (4<sup>th</sup>) that re-acquired autosomal status. Here we use single cell RNA-Seq on fly larvae to demonstrate tha ...[more]