Ontology highlight
ABSTRACT:
SUBMITTER: Ashcroft GS
PROVIDER: S-EPMC154440 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Ashcroft Gillian S GS Mills Stuart J SJ Lei KeJian K Gibbons Linda L Jeong Moon-Jin MJ Taniguchi Marisu M Burow Matthew M Horan Michael A MA Wahl Sharon M SM Nakayama Toshinori T
The Journal of clinical investigation 20030501 9
Characteristic of both chronic wounds and acute wounds that fail to heal are excessive leukocytosis and reduced matrix deposition. Estrogen is a major regulator of wound repair that can reverse age-related impaired wound healing in human and animal models, characterized by a dampened inflammatory response and increased matrix deposited at the wound site. Macrophage migration inhibitory factor (MIF) is a candidate proinflammatory cytokine involved in the hormonal regulation of inflammation. We de ...[more]