Ontology highlight
ABSTRACT:
SUBMITTER: Fex Svenningsen A
PROVIDER: S-EPMC5663815 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Fex Svenningsen Åsa Å Löring Svenja S Sørensen Anna Lahn AL Huynh Ha Uyen Buu HUB Hjæresen Simone S Martin Nellie N Moeller Jesper Bonnet JB Elkjær Maria Louise ML Holmskov Uffe U Illes Zsolt Z Andersson Malin M Nielsen Solveig Beck SB Benedikz Eirikur E
Cellular and molecular life sciences : CMLS 20170719 24
Macrophage migration inhibitory factor (MIF), a small conserved protein, is abundant in the immune- and central nervous system (CNS). MIF has several receptors and binding partners that can modulate its action on a cellular level. It is upregulated in neurodegenerative diseases and cancer although its function is far from clear. Here, we report the finding of a new binding partner to MIF, the serine protease HTRA1. This enzyme cleaves several growth factors, extracellular matrix molecules and is ...[more]