Functional analysis of the murine sarcoma virus RNA packaging sequence.
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ABSTRACT:
SUBMITTER: Izmailova E
PROVIDER: S-EPMC155100 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Publications
Functional analysis of the murine sarcoma virus RNA packaging sequence.
Izmailova Elena E Aldovini Anna A
Journal of virology 20020501 9
We investigated the features of the Moloney murine sarcoma virus leader sequence necessary for RNA packaging function by using a deletion analysis approach. We found that sequences that extend beyond those characterized genetically in previous reports are important for optimal packaging efficiency. A fragment covering a minimum of four potential stem-loop structures is required for the shortest packaging element compatible with gene transfer. Our results reveal the extent to which each of the se ...[more]
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