Ontology highlight
ABSTRACT:
SUBMITTER: Raina D
PROVIDER: S-EPMC1553184 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Raina Deepak D Ahmad Rehan R Kumar Shailendra S Ren Jian J Yoshida Kiyotsugu K Kharbanda Surender S Kufe Donald D
The EMBO journal 20060803 16
The nonreceptor c-Abl tyrosine kinase binds to cytosolic 14-3-3 proteins and is targeted to the nucleus in the apoptotic response to DNA damage. The MUC1 oncoprotein is overexpressed by most human carcinomas and blocks the induction of apoptosis by genotoxic agents. Using human carcinoma cells with gain and loss of MUC1 function, we show that nuclear targeting of c-Abl by DNA damage is abrogated by a MUC1-dependent mechanism. The results demonstrate that c-Abl phosphorylates MUC1 on Tyr-60 and f ...[more]