Ontology highlight
ABSTRACT:
SUBMITTER: Sitz J
PROVIDER: S-EPMC6765264 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Sitz Justine J Blanchet Sophie Anne SA Gameiro Steven F SF Biquand Elise E Morgan Tia M TM Galloy Maxime M Dessapt Julien J Lavoie Elise G EG Blondeau Andréanne A Smith Brandon C BC Mymryk Joe S JS Moody Cary A CA Fradet-Turcotte Amélie A
Proceedings of the National Academy of Sciences of the United States of America 20190909 39
High-risk human papillomaviruses (HR-HPVs) promote cervical cancer as well as a subset of anogenital and head and neck cancers. Due to their limited coding capacity, HPVs hijack the host cell's DNA replication and repair machineries to replicate their own genomes. How this host-pathogen interaction contributes to genomic instability is unknown. Here, we report that HPV-infected cancer cells express high levels of RNF168, an E3 ubiquitin ligase that is critical for proper DNA repair following DNA ...[more]