Ontology highlight
ABSTRACT:
SUBMITTER: Witt CC
PROVIDER: S-EPMC1553189 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Witt Christian C CC Burkart Christoph C Labeit Dietmar D McNabb Mark M Wu Yiming Y Granzier Henk H Labeit Siegfried S
The EMBO journal 20060810 16
The precise assembly of the highly organized filament systems found in muscle is critically important for its function. It has been hypothesized that nebulin, a giant filamentous protein extending along the entire length of the thin filament, provides a blueprint for muscle thin filament assembly. To test this hypothesis, we generated a KO mouse model to investigate nebulin functions in vivo. Nebulin KO mice assemble thin filaments of reduced lengths and approximately 15% of their Z-disks are ab ...[more]