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The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).


ABSTRACT: Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacterium smegmatis shown to be GlcNAc-Ins and mycothiol deficient was sequenced to identify a putative glycosyltransferase gene designated mshA. The ortholog in Mycobacterium tuberculosis, Rv0486, was used to complement the mutant phenotype.

SUBMITTER: Newton GL 

PROVIDER: S-EPMC155378 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature

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The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).

Newton Gerald L GL   Koledin Teresa T   Gorovitz Batia B   Rawat Mamta M   Fahey Robert C RC   Av-Gay Yossef Y  

Journal of bacteriology 20030601 11


Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacterium smegmatis shown to be GlcNAc-Ins and mycothiol deficient was sequenced to identify a putative glycosyltransferase gene designated mshA. The ortholog in Mycobacterium tuberculosis, Rv0486, was used to complement the mutant phenotype. ...[more]

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