Ontology highlight
ABSTRACT:
SUBMITTER: Ninagawa S
PROVIDER: S-EPMC4121980 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Ninagawa Satoshi S Okada Tetsuya T Sumitomo Yoshiki Y Kamiya Yukiko Y Kato Koichi K Horimoto Satoshi S Ishikawa Tokiro T Takeda Shunichi S Sakuma Tetsushi T Yamamoto Takashi T Mori Kazutoshi K
The Journal of cell biology 20140801 3
Glycoproteins misfolded in the endoplasmic reticulum (ER) are subjected to ER-associated glycoprotein degradation (gpERAD) in which Htm1-mediated mannose trimming from the oligosaccharide Man8GlcNAc2 to Man7GlcNAc2 is the rate-limiting step in yeast. In contrast, the roles of the three Htm1 homologues (EDEM1/2/3) in mammalian gpERAD have remained elusive, with a key controversy being whether EDEMs function as mannosidases or as lectins. We therefore conducted transcription activator-like effecto ...[more]