BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.
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ABSTRACT:
SUBMITTER: Rai R
PROVIDER: S-EPMC1557410 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Publications
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.
Rai Rekha R Dai Hui H Multani Asha S AS Li Kaiyi K Chin Koei K Gray Joe J Lahad John P JP Liang Jiyong J Mills Gordon B GB Meric-Bernstam Funda F Lin Shiaw-Yih SY
Cancer cell 20060727 2
BRIT1, initially identified as an hTERT repressor, has additional functions at DNA damage checkpoints. Here, we demonstrate that BRIT1 formed nuclear foci minutes after irradiation. The foci of BRIT1 colocalized with 53BP1, MDC1, NBS1, ATM, RPA, and ATR. BRIT1 was required for activation of these elements, indicating that BRIT1 is a proximal factor in the DNA damage response pathway. Depletion of BRIT1 increased the accumulation of chromosomal aberrations. In addition, decreased levels of BRIT1 ...[more]
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