Ontology highlight
ABSTRACT:
SUBMITTER: Hamilton G
PROVIDER: S-EPMC4861209 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Hamilton Garth G Yee Karen S KS Scrace Simon S O'Neill Eric E
Current biology : CB 20091203 23
Hypermethylation of CpG islands in the RASSF1 promoter is one of the most frequent events identified in human cancer. The epigenetic-driven loss of RASSF1A protein expression is observed more often in tumors of higher grade and correlates with a decreased responsiveness to DNA-damaging therapy. Ras association domain-containing family 1A (RASSF1A) promotes apoptosis by signaling through the MST2 and LATS1 kinases, leading to stabilization of the YAP1/p73 transcriptional complex. Here we provide ...[more]