Microarray evidence of glutaminyl cyclase gene expression in melanoma: implications for tumor antigen specific immunotherapy.

ABSTRACT:

Background

In recent years encouraging progress has been made in developing vaccine treatments for cancer, particularly with melanoma. However, the overall rate of clinically significant results has remained low. The present research used microarray datasets from previous investigations to examine gene expression patterns in cancer cell lines with the goal of better understanding the tumor microenvironment.

Methods

Principal Components Analyses with Promax rotational transformations were carried out with 90 cancer cell lines from 3 microarray datasets, which had been made available on the internet as supplementary information from prior publications.

Results

In each of the analyses a well defined melanoma component was identified that contained a gene coding for the e

SUBMITTER: Gillis JS 

PROVIDER: S-EPMC1557589 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature