Ontology highlight
ABSTRACT:
SUBMITTER: Logtenberg MEW
PROVIDER: S-EPMC7025889 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Logtenberg Meike E W MEW Jansen J H Marco JHM Raaben Matthijs M Toebes Mireille M Franke Katka K Brandsma Arianne M AM Matlung Hanke L HL Fauster Astrid A Gomez-Eerland Raquel R Bakker Noor A M NAM van der Schot Simone S Marijt Koen A KA Verdoes Martijn M Haanen John B A G JBAG van den Berg Joost H JH Neefjes Jacques J van den Berg Timo K TK Brummelkamp Thijn R TR Leusen Jeanette H W JHW Scheeren Ferenc A FA Schumacher Ton N TN
Nature medicine 20190304 4
Cancer cells can evade immune surveillance through the expression of inhibitory ligands that bind their cognate receptors on immune effector cells. Expression of programmed death ligand 1 in tumor microenvironments is a major immune checkpoint for tumor-specific T cell responses as it binds to programmed cell death protein-1 on activated and dysfunctional T cells<sup>1</sup>. The activity of myeloid cells such as macrophages and neutrophils is likewise regulated by a balance between stimulatory ...[more]