Ontology highlight
ABSTRACT:
SUBMITTER: Bibikova M
PROVIDER: S-EPMC1557765 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Bibikova Marina M Chudin Eugene E Wu Bonnie B Zhou Lixin L Garcia Eliza Wickham EW Liu Ying Y Shin Soojung S Plaia Todd W TW Auerbach Jonathan M JM Arking Dan E DE Gonzalez Rodolfo R Crook Jeremy J Davidson Bruce B Schulz Thomas C TC Robins Allan A Khanna Aparna A Sartipy Peter P Hyllner Johan J Vanguri Padmavathy P Savant-Bhonsale Smita S Smith Alan K AK Chakravarti Aravinda A Maitra Anirban A Rao Mahendra M Barker David L DL Loring Jeanne F JF Fan Jian-Bing JB
Genome research 20060809 9
Human embryonic stem (hES) cells originate during an embryonic period of active epigenetic remodeling. DNA methylation patterns are likely to be critical for their self-renewal and pluripotence. We compared the DNA methylation status of 1536 CpG sites (from 371 genes) in 14 independently isolated hES cell lines with five other cell types: 24 cancer cell lines, four adult stem cell populations, four lymphoblastoid cell lines, five normal human tissues, and an embryonal carcinoma cell line. We fou ...[more]