Ontology highlight
ABSTRACT:
SUBMITTER: Silva SS
PROVIDER: S-EPMC2290799 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Silva Susana S SS Rowntree Rebecca K RK Mekhoubad Shila S Lee Jeannie T JT
Proceedings of the National Academy of Sciences of the United States of America 20080313 12
With the potential to give rise to all somatic cell types, human embryonic stem cells (hESC) have generated enormous interest as agents of cell replacement therapy. One potential limitation is their safety in vivo. Although several studies have focused on concerns over genomic stability ex vivo, few have analyzed epigenetic stability. Here, we use tools of the epigenetic phenomenon, X-chromosome inactivation (XCI), to investigate their epigenetic properties. Among 11 distinct hESC lines, we find ...[more]