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Helicobacter pylori infection induces interleukin-8 receptor expression in the human gastric epithelium.

ABSTRACT: The gastric pathogen Helicobacter pylori is known to activate multiple proinflammatory signaling pathways in epithelial cells. In this study, we addressed the question of whether expression of the interleukin-8 receptors IL-8RA (CXCR1) and IL-8RB (CXCR2) is upregulated in H. pylori-infected human gastric biopsy samples. Biopsy samples from patients infected with H. pylori strains harboring the cag pathogenicity island (PAI) expressed larger amounts of both receptors. In addition, IL-8RB expression was induced in the gastric epithelial cell line AGS upon infection with a clinical isolate containing the cag PAI, while a strain lacking the cag PAI did not. Our finding suggests that gastric epithelial cells express IL-8R in response to H. pylori infection.

SUBMITTER: Backhed F

PROVIDER: S-EPMC155779 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature

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Helicobacter pylori infection induces interleukin-8 receptor expression in the human gastric epithelium.

Bäckhed Fredrik F Torstensson Elisabeth E Seguin Delphine D Richter-Dahlfors Agneta A Rokbi Bachra B

Infection and immunity 20030601 6

The gastric pathogen Helicobacter pylori is known to activate multiple proinflammatory signaling pathways in epithelial cells. In this study, we addressed the question of whether expression of the interleukin-8 receptors IL-8RA (CXCR1) and IL-8RB (CXCR2) is upregulated in H. pylori-infected human gastric biopsy samples. Biopsy samples from patients infected with H. pylori strains harboring the cag pathogenicity island (PAI) expressed larger amounts of both receptors. In addition, IL-8RB expressi ...[more]

PMID: 12761119

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