Ontology highlight
ABSTRACT:
SUBMITTER: Johnson R
PROVIDER: S-EPMC1557810 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Johnson Rory R Gamblin Richard J RJ Ooi Lezanne L Bruce Alexander W AW Donaldson Ian J IJ Westhead David R DR Wood Ian C IC Jackson Richard M RM Buckley Noel J NJ
Nucleic acids research 20060809 14
The genome-wide mapping of gene-regulatory motifs remains a major goal that will facilitate the modelling of gene-regulatory networks and their evolution. The repressor element 1 is a long, conserved transcription factor-binding site which recruits the transcriptional repressor REST to numerous neuron-specific target genes. REST plays important roles in multiple biological processes and disease states. To map RE1 sites and target genes, we created a position specific scoring matrix representing ...[more]